Since its foundation, the museum in Kruševac performs its activity through preservation and protection of the movable archaeological finds. The collection is primarily being formed with the help of researches of the numerous archaeological localities, as well as by means of donations and purchases.

The collection of prehistoric artefacts includes material remains from the period of the Neolithic, Bronze Age and Iron Age, covering a wide time travel between the end of VII B.C. and the Roman conquest of this area.

The antique archaeological collection specializes in studying the regional past during the Roman epoch. Within the very collection are the votive monuments, bronze figurines, reliefs made of stone, terracotta and lead, fibulae, jewellery, tools, weapons, ceramics … The interpretation of the acquired finds, combined with the historical sources and terrain researches, enabled the creation of the basic image of the area of Kruševac in the antique period.

The medieval archaeological collection happened to be founded through the first systematic archaeological excavations of the medieval Kruševac, conducted in 1961 by the Republic Institute for Protection of Cultural Monuments and the Institute of Archaeology from Belgrade. The collection has been complemented over time with the objects collected in numerous archaeological excavations and terrain reconnaissance, as well as through donations and purchases. It consists of three units defined by the significant centres of Moravian Serbia – Kruševac, Stalać and Koznik.

As specific segments one should take the artefacts resulting from the archaeological researches of the localities Konopljara near Čitluk and Bedem near the village Maskare.

According to the standardized division, there are three sub-collections within the collection: pottery, weapons and tools.